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This page lists common issues with people either installing or using their mod, which may lead to incorrect behavior or game crash.
If you are using MTR 4, make sure that all the MTR addon mods you are using is compatible with MTR 4.
A notable case is the Nemo Transit Expansion (MTR-NTE/NTE) addon mod which has NOT been updated to MTR 4. Note that MTR 4 already integrated much of NTE's functionality (Such as optimization/OBJ rendering/Decoration Block), with the exception of Scripting and a few other cosmetic blocks.
This may be due to your GPU not being able to handle displaying such a high resolution image, tuning the resolution down by following the steps below may help: